Following Raja Rani 's success, Atlee went on to direct his next hit film ‘Theri’ (2016) an emotional-action thriller, produced by Kalaipuli S. Thanu , starring Thalapathy Vijay, Samantha and Amy Jackson in the lead roles. The film released worldwide receiving positive reviews from critics who praised the cast performances, soundtrack and the making of the film.

Known for his larger-than-life narratives, he skilfully weaves together engaging plots, intense action sequences, and emotional depth to create memorable cinematic experiences. Atlee's films often tackle socially relevant themes and carry impactful messages, resonating with audiences of all ages.

In 2017, Atlee went on to direct Mersal, an action film, produced by Thenandal Studio Ltd. starring Thalapathy Vijay, Samantha and Nithya Menen while S. J. Surya, Sathyaraj, Vadivelu, Hareesh Peradi, Kajal Aggarwal, Samantha Ruth Prabhu and Kovai Sarala appear in pivotal supporting roles. The film was a commercial success becoming one of the highest-grossing films in Tamil cinema.

Atlee soon directed his next film Bigil, an action film, produced by Kalpathi S. Aghoram under the banner AGS Entertainment. The film stars Vijay in the titular role along with Nayanthara, Jackie Shroff, Vivek and Kathir in other prominent roles. The film marked the third collaboration of Vijay and Atlee after Theri and Mersal. Bigil emerged as the highest-grossing Tamil film of 2019.

He also ventured into producing films. In 2017, Atlee along with his wife Priya Atlee, started their own production house called " A for Apple Production " and produced their debut movie ‘Sangili Bungili Kadhava Thora’. In 2020, they produced yet another film Andhaghaaram, a supernatural horror film.

With his keen eye for detail and ability to extract powerful performances from his actors, Atlee has established himself as a sought-after director. His collaborations with top actors and technicians have consistently delivered box office hits, making him one of the most promising and influential directors of his generation.

His Bollywood debut film, 'Jawan,' featuring Shah Rukh Khan, was released on September 7, 2023, and it created a blockbuster 'dhamaka' at the box office, amassing an impressive collection of over 1,133 crores.